Effects of Continuous Glucose Monitoring on Impaired Awareness of Hypoglycemia in Older Adults With Type 1 Diabetes: A Post Hoc Analysis of the WISDM Study
Year: 2025
Type: other
Abstract: Objective: While continuous glucose monitoring (CGM) reduces hypoglycemia and may improve impaired awareness of hypoglycemia (IAH), its effectiveness in high-risk older adults remains unknown. Research Design and Methods: This post hoc analysis of the WISDM study focuses on CGM use over 52 weeks. IAH was assessed using the Clarke-full score and its subscales: Hypoglycemia Awareness Factor (HAF) and Severe Hypoglycemia Experienced Factors (SHEF) at baseline, 26 weeks, and 52 weeks Results: After 26(n=184) and 52 weeks(n=94) of CGM use, Clarke-SHEF decreased significantly (p=0.02 and p<0.0001 respectively) while Clarke-full and Clarke-HAF remained unchanged. After 52 weeks, IAH subgroup improved Clarke-full but not Clarke-HAF score, highlighting the importance of selecting the appropriate scoring method for IAH. Conclusions: In older adults with type 1 diabetes, CGM improves hypoglycemia, however, its role in improving IAH is variable depending on the scoring methods. The study highlights the limitations of Clarke score.
Authors: Anika Bilal, Fanchao Yi, Keri Whitaker, Zahra A. Khan, Richard Pratley, Anna Casu
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4413965401