Year: 2025
Type: article
Abstract: This study introduces a simple signal transduction system that mimics the receptor tyrosine kinase mechanism by employing amphiphilic receptors embedded in lipid bilayers. The designed receptors carry bisphosphonate head groups and feature aggregation-induced emission enhancement (AIEE) properties. Upon addition of polyammonium messengers, they undergo ligand-induced dimerization or clustering inside the membrane. Steric restriction of intramolecular motion in the AIE luminophores sends out a fluorescence signal. Systematic comparative studies highlight the impact of receptor design, lipid environment and messenger properties on the efficiency, kinetics, and strength of signal transduction. These findings provide new insight into the interplay between receptor aggregation and membrane organization in controlling fluorescence-based signaling systems. Practical perspectives and inherent limitations are critically discussed.
Source: ChemPlusChem
Institution: University of Duisburg-Essen
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,030
OpenAlex ID: W4413965995