Work

Langerhans Cell Histiocytosis and Erdheim-Chester Disease: A Case Report of Atypical Imaging Overlap

Year: 2025

Type: article

Abstract: Histiocytoses are rare disorders characterized by abnormal proliferation of histiocytic cells in tissues and organs. They have a broad clinical spectrum and are traditionally categorized as Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (N-LCH), but recent evidence highlights a molecular and clinical overlap between LCH and a type of N-LCH known as Erdheim-Chester disease (ECD). While both disorders have distinct features, up to 20% of ECD patients may present with concurrent LCH lesions. Overlap between LCH and ECD is increasingly recognized, but reports of imaging of this phenomenon are scarce. Here, we present a rare case of directly contiguous LCH and ECD lesions in a 69-year-old woman and discuss the radiologic and histopathologic findings as well as the classification of these findings within the revised histiocytosis system.

Source: The UCLA Radiological Science Proceedings

DOI: 10.5070/rs4.42486

Authors: Wendy Qiu, Zaid Patel, Benjamin Emert, Varand Ghazikhanian

Institution: University of California, Los Angeles

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4413968540