Work

Three New Prenylated Dihydrobenzofurans and a New Flavonoid Glycoside from the Aerial Parts of Myrsine seguinii

Year: 2025

Type: article

Abstract: In this study, we aimed to determine the chemical constituents of M. seguinii, which led to the isolation and identification of 26 compounds. Three new prenylated dihydrobenzofurans [myrsinoic acids I (1), J (2), and K (3)] and a new flavonoid glycoside, mearnsetin 3-O-α-L-arabinopyranoside (4), were discovered, and the absolute configuration of the known compound, myrsinoic acid B (5), was re-established. To ensure the structural accuracy of these compounds, comprehensive spectroscopic analyses were performed, including one- and two-dimensional nuclear magnetic resonance spectroscopy, mass spectrometry, and circular dichroism spectroscopy. In addition, computational analysis methods such as density functional theory (DFT)-based Electronic Circular Dichroism (ECD) simulations and Gauge-Including Atomic Orbitals (GIAOs) 1H and 13C NMR chemical shift calculations with DP4+ probability analysis were utilised to further support the structural assignments.

Source: Molecules

DOI: 10.3390/molecules30163385

Authors: Youngwoo Jin, Hye Jin Kim, Kye Jung Shin, Khin Myo Htwe, Kee Dong Yoon

Institution: Catholic University of Korea

Language: English

Topic: Bioactive natural compounds

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: National Research Foundation, National Research Foundation of Korea