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Daphnetin alleviates renal inflammation, oxidative stress, and apoptosis in septic rats via the JAK2/STAT3 signaling pathway.

Year: 2026

Type: article

Abstract: experiments showed that DAP or AG490 (a JAK2 inhibitor) alleviated LPS-induced apoptosis, inflammation, and oxidative stress. In conclusion, DAP attenuates sepsis-induced AKI by reducing inflammation, oxidative stress, and apoptosis via the inactivation of the JAK2/STAT3 pathway.

Source: PubMed

DOI: 10.14670/hh-18-978

Authors: Zhuo Zhang, Pan Hu, Qingye Li, Yingling Wang, Ruliang Yao

Institution: Hubei Provincial Hospital of Traditional Chinese Medicine

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4413970002

FWCI:

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