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Apoptosis and Brain Dervived Neurotrophic Factor are increased in cortical neurons of Marfan Syndrome mice

Year: 2025
Type: article
Abstract: gene. There is a gap in our understanding of the impact of monogenic connective tissue aberrations on the brain. This study aimed to determine the impact of MFS on neurodegeneration in the cortical brain tissue of mice. We report increased levels of apoptosis in neurons within the sensory and motor cortical areas of female MFS mice. Additionally, we also report increased levels of neuronal plasticity in cortical brain tissue of both male and female MFS mice.
Source: PubMed
DOI: 10.17912/micropub.biology.001651
Authors: Mitra Esfandiarei, Faizan Anwar, Manogna Nuthi, Alisha Harrison, Mary Eunice Barrameda, Tala Curry-Koski, Kasey Pull, Theresa Currier Thomas, Nafisa Jadavji
Language: English
Subfield: Genetics
Open Access status: green
OpenAlex ID: W4413970133
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