Effect of Nanoemulsion Carbonated Hydroxyapatite-Statin Administration on the Alkaline Phosphatase Level during Orthodontic Relapse in Rats.
Year: 2025
Type: article
Abstract: Background: Relapse is acknowledged as a substantial failure after orthodontic correction. As a biomarker of bone formation, alkaline phosphatase (ALP) levels will decline in compressive sites during relapse subsequent to orthodontic tooth displacement. Manipulating alveolar bone remodeling to elevate ALP levels using novel biomaterial is presently regarded as one of the innovative approaches to avert relapse effectively. Purpose: This study aimed to evaluate the effect of carbonated hydroxyapatite (CHA)-statin nanoemulsion on ALP levels in relapsed rats. Materials and Method: < 0.05. Results: > 0.05). Conclusion: The results indicated that nanoemulsion CHA-statin could elevate ALP levels during orthodontic relapse.
Source: PubMed
Institution: Universitas Gadjah Mada
Language: English
Subfield: Orthodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4413970532