Palladium-Catalyzed C–H Arylation of Quinoidal Scaffolds Through Homogeneous and Heterogeneous Pathways: Advancing Toward Trypanocidal Prototypes

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A Pd-mediated C–H activation methodology was developed for the direct arylation of quinoidal skeletons, both by means of homogeneous catalysis and heterogeneous catalysis using metal-decorated carbon nanotubes, enabling the direct functionalization of quinones in moderate to excellent yields. The derivatives obtained were tested against trypomastigote forms of Trypanosoma cruzi, showing promising biological activity.

Source: ACS Omega

DOI: 10.1021/acsomega.5c05006

Authors: José M. C. Tavares Junior, Eduardo F. S. Guimarães, Mateus P. Nunes, Renata G. Almeida, Maria H. Araujo, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, Joel A. Tchuiteng Kouatchou, Edmond Gravel, Eric Doris, Guilherme A. M. Jardim, Eufrânio N. da Silva Júnior

Institutions: Universidade Federal de Minas Gerais, Fundação Oswaldo Cruz, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, CEA Paris-Saclay - Etablissement de Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Médicaments et Technologies pour la Santé

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funders: Agence Nationale de la Recherche, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais

OpenAlex ID: W4413971298