Work

Evaluating the molecular function of zebrafish Anoctamin 1a

Year: 2025

Type: article

Abstract: ) are genetically similar to humans, easily manipulated, and are a valuable model organism. We cloned zebrafish Anoctamin 1, a putative CaCC gene, expressed it in mammalian cells, and confirmed its function via halide flux assays. The channel conducted anions and responded to calcium, verifying its role as a CaCC. These findings confirm the functionality of zebrafish CaCCs and lay the groundwork to use the organism to model human physiology and disease.

Source: PubMed

DOI: 10.17912/micropub.biology.001706

Authors: Amanda Dimatteo, Nicole Stango, Adam Rich, Tara Sweet

Institutions: SUNY Geneseo, SUNY Brockport

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4413971306

FWCI:

Cites: 35

Cited by:

Related to: 10