Work

Evaluation of the Safety of A Novel Anti-HER2 Immunotoxin Containing Modified Fragment of Pseudomonas Exotoxin in BALB/C Mice.

Year: 2025

Type: article

Abstract: Background: efficacy studies. This study aimed to evaluate the acute toxicity of scFv-PE35KDEL in BALB/c mice. Objectives: and monitoring body weight changes in BALB/c mice following injection. Materials and Methods: of immunotoxin. Mice's weight, body temperature, and acute toxicity symptoms were evaluated every odd day for two weeks. Histopathological evaluation of the kidney, liver and lungs was performed. Results: . Conclusion: evaluations are required.

Source: PubMed

DOI: 10.30498/ijb.2025.481960.4000

Authors: Fatemeh Saadatkhah, Valiollah Hajhashemi, Azar Naimi, Vajihe Akbari, Melika Kolahdoozan

Institution: Isfahan University of Medical Sciences

Language: English

Topic: Toxin Mechanisms and Immunotoxins

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4413972174

FWCI:

Cites: 33

Cited by:

Related to: 10