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Rapidly Progressive Metastatic Adrenocortical Carcinoma With Oncocytic Features in a Young Male: A Case Report

Year: 2025

Type: article

Abstract: Adrenocortical carcinoma (ACC) is a rare but highly aggressive endocrine malignancy, often diagnosed at an advanced stage with limited treatment options and a poor prognosis. We present the case of a 29-year-old male who presented with pleuritic chest pain and was found to have a large right abdominal mass with widespread metastatic disease. Histological analysis revealed ACC with oncocytic features, a rare and distinct variant of ACC. Despite prompt diagnostic work-up and supportive care, the patient deteriorated rapidly. This case underscores the diagnostic challenges and dire prognosis associated with ACC and highlights the importance of early detection, multidisciplinary evaluation, and genetic testing with or without family history.

Source: Cureus

DOI: 10.7759/cureus.91554

Authors: Sultana Jannatun Nahar, G K M Rashik Uzzaman, Ibnul Shams, Muhammad Asif Iqbal Rao, Cornelius Fernandez

Institution: United Lincolnshire Hospitals NHS Trust

Language: English

Topic: Adrenal and Paraganglionic Tumors

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413972660