Severe invasive Streptococcus pyogenes infections: A 15-year observational study with molecular characterization of isolates among intensive care adults
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: (iGAS) infections is an unmet clinical need. The main objective of this study was to analyze epidemiological and outcome differences in adults admitted to the intensive care unit (ICU) with iGAS infection over a 15-year period and to evaluate the impact of M1uk isolates and clindamycin optimization on patient outcomes. Methods: <0.05 was considered for all analyses. Results: =0.090) among those adults who did not receive clindamycin in the emergency department. Conclusions: The incidence of iGAS infections requiring ICU admission showed no significant increase post-Coronavirus Disease-19 pandemic. The highly toxigenic M1uk strain became predominant, but it was not associated with worse mortality among adult ICU patients.
Source: Journal of Intensive Medicine
Institutions: Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Biogipuzkoa Health Research Institute, Osakidetza, Donostiako Unibertsitate Ospitalea, Université de Montpellier, Vall d'Hebron Institut de Recerca, Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,100
OpenAlex ID: W4413975266