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Hematologic Variations in Children With Down Syndrome

Year: 2025

Type: article

Abstract: Hematologic abnormalities in children with Down Syndrome (DS) have previously been described, but with inconsistent conclusions. A retrospective single-institution cohort study was conducted to evaluate complete blood count (CBC) ranges in children with DS. Mean values for CBC results are presented by age and sex, as a clinical resource for the evaluation of DS children. In comparison to reference values, children with DS had higher mean corpuscular volume (MCV), lower absolute lymphocyte count, and a trend toward higher hemoglobin (Hgb) values. The presence of these findings across the cohort suggests that these are benign hematologic variations in DS.

Source: Journal of Pediatric Hematology/Oncology

DOI: 10.1097/mph.0000000000003092

Authors: Golda Grinberg, Gwen Sokoloff, Beverly Hay, Stefanie Lowas

Institutions: Children's Medical Center, The University of Texas Southwestern Medical Center, University of Massachusetts Chan Medical School, UMass Memorial Health Care, Harvard University, UMass Memorial Medical Center

Language: English

Topic: Down syndrome and intellectual disability research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4413976256

FWCI: 0.847

Cites: 15

Cited by: 1

Related to: 10