Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing
Year: 2025
Type: other
Abstract: Diabetic wounds represent a significant clinical and economic burden, affecting both patients and healthcare systems. While current therapeutic approaches such as negative pressure wound therapy offer benefits, their limitations necessitate alternative strategies. Newly discovered dental pulp stem cell-derived intracellular vesicles have emerged as a promising candidate in regenerative medicine due to their therapeutic potential. In vitro assessments using HUVECs, HACATs, and RAW264.7 cells revealed that intracellular vesicles enhanced cell migration, angiogenesis, and proliferation while suppressing the cGAS-STING pathway. Additionally, intracellular vesicles promoted M2 macrophage polarization and maintained mitochondrial function. In a diabetic mouse wound model, both intracellular vesicles and negative pressure wound therapy individually improved wound healing, but their combination exhibited a synergistic effect, resulting in faster wound closure, enhanced angiogenesis, and reduced inflammation. The combined treatment also exhibited excellent biocompatibility. These findings highlight the therapeutic potential of intracellular vesicles as an adjunct to negative pressure wound therapy for diabetic wound treatment.
Authors: Pengcheng Pang, Yonghao Liu, Haicheng Song, Zhifei Ye, Heng Zhou, Rui Zhang, Tushar Kumeria, Wenting She, Chun Xu, Peter L Mei, Yan He, Qingsong Ye
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4413981849