Work

Rapid and Esthetic Wound Healing in Surgery by Applying a Powdered Mixture of Mannose and Calcium Propionate

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: BACKGROUND: Wound healing is a current problem in surgery. Wounds most commonly occur from surgery, accidents, and burns. The purpose of this study was to reduce bleeding time and wound healing time as well as prevent or mitigate scarring by applying D-mannose with calcium propionate mixtures directly to the wound in powder form. METHODS: This study was a placebo, randomized, double-blind, crossover experiment involving a single group of twenty-five subjects. The number of incisions made was equal to the number of treatments required. Each subject had one incision per day. Only one treatment was applied to each wound. By the end, each subject was treated with all test mixtures and the placebo substance. RESULTS: The results show that the bleeding time can be reduced to about 50% compared to D-mannose when treating the wound with a mixture containing 20-60 moles of D-mannose per 1 mole of powdered calcium propionate. The wound healing time was reduced by about 40% compared to D-mannose. No visible scarring was observed after 40 days on skin treated with the mannose and calcium propionate mixture. CONCLUSIONS: Bleeding time can be reduced by approximately 50% when the wound is treated with a mixture containing 40 moles of D-mannose per 1 mole of calcium propionate and wound healing time by approximately 40% compared to D-mannose. Both substances contribute to the destruction of pathogens and to the processes of new tissue formation, which accelerates the healing process. Treatment with this powdered mixture prevents skin scarring. LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Source: Aesthetic Plastic Surgery

DOI: 10.1007/s00266-025-05186-z

Authors: Cristian Ionuţ Ciucanu, Sonia Raţiu, Sorin Olariu, Ionel Ciucanu

Institutions: Victor Babeș University of Medicine and Pharmacy Timișoara, West University of Timişoara

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,790