Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS). METHODS AND RESULTS: We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three age groups: ≤50 years (9%), 51-74 years (48%), and ≥75 years (43%). In the youngest group, compared to the middle-aged and the oldest groups, patients were more likely to be male (35% vs. 16% and 14%, p = .01), have a physical trigger (65% vs. 43% and 49%, p = .04), exhibit atypical echocardiographic patterns (27% vs. 11% and 11%, p = .02), and experienced a higher incidence of ventricular arrhythmias (24% vs. 8% and 7%, p = .01). In-hospital mortality rates were 5% in younger patients, 12% in middle-aged patients, and 15% in older patients (p = .15). Older age independently predicted both in-hospital mortality (OR 2.33, 95% CI 1.05-5.17; reference: middle-aged) and 5-year mortality (HR 3.69, 95% CI 1.77-7.67), regardless of shock severity. CONCLUSIONS: In CS-TTS, younger patients exhibit distinct clinical features but have better outcomes. Older age is associated with higher in-hospital and long-term mortality, regardless of comorbidities and shock severity. These findings underscore the need for age-specific management strategies and further research into the mechanisms underlying age-related differences in CS-TTS.
DOI: 10.1111/eci.70119
Authors: Marco Tomasino, Ravi Vazirani, Jorge Salamanca, Sergio Raposeiras‐Roubin, Clara Fernández‐Cordón, Miguel Corbí‐Pascual, Oscar Vedia, Agustín C. Martín‐García, Emilia Blanco‐Ponce, Manuel Almendro Delia, Alberto Piserra‐López, Jaime Francisco Larre Guerra, Francisco Gonzalez‐Santorum, Carmen Lluch‐Requerey, Marta Guillén‐Marzo, Alberto Pérez‐Castellanos, Francisco Ridocci‐Soriano, Javier Lopez‐País, Rut Andrea, Alessandro Sionis, Iván J. Núñez‐Gil, Aitor Uribarri
Institutions: Universitat Autònoma de Barcelona, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Hospital Clínico San Carlos, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Hospital Clínico Universitario de Valladolid, Hospital General Universitario de Albacete, Complejo Hospitalario Universitario de Albacete, Hospital Universitario de Torrejón, Complejo Hospitalario de Salamanca, Centro de Investigación Biomédica en Red, Hospital Universitari Arnau de Vilanova, Hospital Universitario Virgen Macarena, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Fundación Jiménez Díaz, Hospital Juan Ramón Jiménez, Hospital Universitari Joan XXIII de Tarragona, Hospital Universitario Son Espases, Hospital General Universitario De Valencia, Complejo Hospitalario Universitario de Santiago, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Hospital de Sant Pau, Universidad Europea de Madrid
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,100
OpenAlex ID: W4413987712