ASO Therapy Targeting STAU2 to Inhibit Pancreatic Ductal Adenocarcinoma Progression and Metastasis by Regulating the PALLD‐Mediated EMT Signaling Pathway (Adv. Sci. 33/2025)
Year: 2025
Type: article
Abstract: STAU2-ASO Therapy for Pancreatic Ductal Adenocarcinoma The cover is inspired by the Chinese mythological novel Journey to the West. The Monkey King wields weapon with STAU2-ASO to targeting strike STAU2 (monster's torso) -PALLD (monster's tail). The absence of STAU2 leads to PALLD RNA degradation (tail disintegration), thereby inhibiting the metastasis of tumor cells (stones in monster's hands and on the mountain) from the pancreas (ochre mountain) to the liver (reddish-brown mountain). More details can be found in article number 2506718 by Peng Yang, Xiao Wang, Jiayu Ding, Hao Shen, and co-workers.
Source: Advanced Science
DOI: 10.1002/advs.71431
Authors: Jiayu Ding, Hao Shen, Jiaying Ji, Jiaxing Li, Zhongrui Shi, Xuejiao Wang, Bangbang Li, Yi Hou, Wenjian Min, Chengliang Sun, Kai Yuan, Yasheng Zhu, Liping Wang, Shun‐Qing Liang, Wenbin Kuang, Xiao Wang, Peng Yang
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,730
OpenAlex ID: W4413988284