Year: 2025
Type: article
Abstract: The complex architecture of neurons poses unique challenges in maintaining proteome balance. Lysosomes, cellular metabolic hubs and main degradative organelles, play a central role in this process, thus supporting synaptic activity. Recent findings suggest that a specialized subpopulation of lysosomes in dendrites fuse with plasma membrane and release aggregation-prone proteins to the extracellular space. At the same time, they lead to structural changes in synapses, an intriguing link between the control of protein concentration and structural synaptic plasticity.
Source: BIOspektrum
Author: Katarzyna M. Grochowska
Institution: University Medical Center Hamburg-Eppendorf
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,190
OpenAlex ID: W4413990032