Work

Wie Tau die Reaktionen von Mikroglia in Tauopathien beeinflusst

Year: 2025

Type: article

Abstract: Neuroinflammation and tau aggregation are hallmarks of tauopathies. Microglial NLRP3 inflammasome activation, initiated by tau, is a key mediator in these diseases, resulting in the release of pro-inflammatory IL-1β and neuronal damage. However, microglia can also present with other disease-associated states such as cellular senescence, which can be driven by tau. Senescent microglia are characterized by a sustained cytokine release, exacerbating disease progression.

Source: BIOspektrum

DOI: 10.1007/s12268-025-2526-5

Authors: Jana Caroline Hollenbeck, Christina Ising

Institutions: University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,190