Year: 2024
Type: article
Abstract: INTRODUCTION Associations between amyloid‐tau‐neurodegeneration (ATN) plasma biomarkers and cognition have not been characterized in adults with type 1 diabetes (T1D). METHODS Using data from participants in the Glycemic Variability and Fluctuations in Cognitive Status in Adults with T1D (GluCog) study ( N = 114), we evaluated associations between phosphorylated tau (pTau)181, pTau217, β‐amyloid 42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) and self‐administered digital cognitive tests, adjusting for age, sex, education, comorbidities (e.g., kidney disease), and glycemic indices. RESULTS Higher concentrations of pTau181 and GFAP were associated with slower responses on working memory tasks (pTau181: β = 0.261; p = 0.007; GFAP: β = 0.175, p = 0.036), and higher β‐amyloid 42/40 ratio was associated with better vocabulary ( β = 0.260, p = 0.009). Discussion Digital cognitive performance was associated with several ATN plasma biomarkers in T1D adults. Prospective studies are needed to understand the utility of these biomarkers in T1D. Highlights There is an increase in life expectancy for individuals with type 1 diabetes (T1D). Few studies investigate the relationship between T1D and neurodegeneration. We characterize the relation between ATN plasma biomarkers and cognitive function. Digital cognitive performance was associated with plasma biomarkers in T1D adults.
DOI: 10.1002/dad2.70029
Institutions: Washington State University Spokane, Universidade de São Paulo, Rutgers, The State University of New Jersey, Harvard University, McLean Hospital, Washington State University, SUNY Upstate Medical University, Jaeb Center for Health Research, Pennsylvania State University, Brigham and Women's Hospital, Massachusetts General Hospital
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,310
Awards: G138294872, AD Biomarkers, Vascular Risk Factors and Cognitive Variability in Aging T1D, Glycemic Variability and Fluctuations in Cognitive Status in Adults with Type 1 Diabetes, Intraindividual cognitive variability in aging adults with Down syndrome: associations with Alzheimer's disease plasma biomarkers, neuropathology and clinical dementia, University of Washington Alzheimer's Disease Research Center, Massachusetts Alzheimer's Disease Research Center (MADRC), New York Regional Center for Diabetes Translation Research
OpenAlex ID: W4403687332