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Cholesterol Levels Are Not Associated with Peripheral Blood Stem Cell Mobilization in Healthy Donors

Year: 2025

Type: article

Abstract: Background/Objectives: Hematopoietic stem cell (HSCs) mobilization from the bone marrow to the peripheral blood (PB) is a critical step in stem cell transplantation. Although some experimental studies have suggested that cholesterol levels may affect this process, the clinical relevance of lipid profiles in healthy donors remains unclear. This study aimed to investigate whether serum cholesterol parameters are associated with peripheral blood CD34+ HSC mobilization in healthy stem cell donors. Methods: A total of 251 healthy donors who underwent granulocyte colony-stimulating factor (G-CSF)-based mobilization were retrospectively analyzed. Peripheral blood CD34+ cell counts and yields (×106/kg) were recorded. Laboratory parameters, including total cholesterol, HDL-C, LDL-C, and triglyceride levels were evaluated. Correlations between mobilization outcomes and donor characteristics or laboratory findings were also assessed. Results: No significant association was found between serum lipid parameters (total cholesterol, LDL-C, HDL-C, triglycerides) and CD34+ cell mobilization or yield. However, white blood cell count, hemoglobin level, platelet count, absolute neutrophil count, and lymphocyte count showed significant positive associations with mobilization efficacy. In contrast, body mass index (BMI) was inversely correlated with CD34+ cell yield. Conclusions: Serum cholesterol levels do not appear to influence stem cell mobilization outcomes in healthy donors. Classical hematologic parameters remain reliable predictors of CD34+ cell yield. These findings suggest that cholesterol is not a suitable biomarker for predicting mobilization efficiency in this population group.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm14176239