Work

The Role of Intracellular Bacterial Communities of Uropathogenic Escherichia Coli in Chronic Urinary Tract Infection and New Therapeutic Ideas

Year: 2025

Type: article

Abstract: Escherichia coli is the primary pathogen responsible for urinary tract infections (UTI), accounting for approximately 75% of uncomplicated and more than 50% of complicated cases. Its ability to invade intracellularly and form IBCs allows the bacteria to multiply while evading antibiotics and the host’s immune system. E. coli has developed virulence factors that facilitate intracellular invasion, while the plasticity of its genome enables ongoing evolution and adaptation to diverse environments. At present, no available therapy fully eradicates IBCs, highlighting the urgent need for innovative treatment strategies. All methods discussed in this paper address recurrent UTIs and the eradication of IBCs. Among the most promising strategies are the development of new antibiotics, the use of adjunctive agents that enhance intracellular penetration, inhibitors of bacterial adhesion to epithelial cells, and engineered bacteriophages.

Source: Current Clinical Microbiology Reports

DOI: 10.1007/s40588-025-00253-0

Authors: Anna Dziuba, Jakub Białek, Monika Wawszczak-Kasza, Jakub Janczura, Julia Dulębska

Institution: Jan Kochanowski University

Language: English

Topic: Escherichia coli research studies

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,790