Work

Extracellular matrix biomimetics for pancreatic tissue engineering

Year: 2025

Type: article

Abstract: Isolated islet transplantation offers a safer and less invasive alternative to whole pancreas transplantation for patients with complicated type 1 diabetes mellitus. However, the procedure faces significant challenges, including the loss of vascularization, innervation, and extracellular matrix (ECM) support. Additionally, factors such as hypoxia, oxidative stress, inflammatory responses, and the cytotoxic effects of immunosuppressive therapy compromise islet viability significantly and limit long-term graft function. Tissue engineering and regenerative medicine strategies aim to address these challenges. A central objective is the development of biocompatible, biomimetic ECM scaffolds (frameworks, carriers, or matrices) that can provide both mechanical support and a suitable microenvironment for islet cells in vitro and in vivo. This review aims to systematize current data on the use of biomimetic ECMs in the creation of stable, tissue-engineered pancreatic constructs.

Source: Russian Journal of Transplantology and Artificial Organs

DOI: 10.15825/1995-1191-2025-3-146-159

Authors: A. S. Ponomareva, N. V. Baranova, Yu. B. Basok, V. I. Sevastianov

Institution: V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413996654

FWCI: 0.892

Cites: 107

Cited by: 1

Related to: 10