Work

Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitro

Year: 2025

Type: article

Abstract: The retinal photopigment melanopsin is also expressed in subcutaneous white adipose tissue (scWAT). Through melanopsin, light can modulate scWAT metabolism, but its impact on circadian phase is unclear. In vitro exposure of murine scWAT to bright light at different times over 24 h did not elicit phase shifts, unlike the response to corticosterone. This finding suggests that the direct impact of bright light on scWAT metabolism occurs in a circadian-independent manner.

Source: npj Biological Timing and Sleep

DOI: 10.1038/s44323-025-00048-y

Authors: Anna Edmondson, Charley Beresford, Jan-Frieder Harmsen

Institutions: MRC Laboratory of Molecular Biology, University of Cambridge, Maastricht University Medical Centre, Maastricht University, RWTH Aachen University

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590