Work

Petasites japonicus‑propolis mixture attenuates airway inflammation in a mouse model of PM10 and ovalbumin‑induced respiratory disease

Year: 2025

Type: article

Abstract: Airway inflammation driven by particulate matter (PM) exposure underlies diseases such as asthma and allergic rhinitis.Although conventional anti-inflammatory therapies exist, they often cause significant side effects.Natural plant extracts offer non-toxic alternatives with comparable efficacy.The present study evaluated the effects of Petasites japonicus-propolis (PJP) mixture in a mouse model co-exposed to PM (intranasal) and ovalbumin (OVA; intraperitoneal) over 30 days.PJP was administered orally at 50, 100 or 200 mg/kg daily for 9 days.PJP reduced sneezing and nasal rubbing.Serum levels of total IgE and OVA-specific IgG 1 were decreased by PJP.In addition, bronchoalveolar lavage fluid and nasal lavage fluid showed lower histamine and IL-4 concentrations.In lung tissue, PJP reduced the epithelial thickness and inflammatory cell infiltration (goblet cells, eosinophils and mast cells).At the molecular level, PJP downregulated suppression of tumorigenicity 2, IL-33, TNF-α and IL-4 expression, and inhibited NF-κB phosphorylation.PJP attenuated PM/OVA-induced airway inflammation by suppressing NF-κB signaling and associated cytokine responses, highlighting its potential as a therapeutic candidate for inflammatory respiratory diseases.

Source: Experimental and Therapeutic Medicine

DOI: 10.3892/etm.2025.12950