Work

M1-like macrophages regulate T cell infiltration in colorectal cancer through P2X4 receptor

Year: 2025

Type: article

Abstract: but also augmented T cell responses in a syngeneic CRC mouse model. Clinically, reduced P2X4 expression in CRC tissues correlated with poorer prognosis. In conclusion, these findings identify the P2X4R as a key regulator of M1-like TAM polarization, representing a promising target to reprogram TAMs and suppress CRC progression.

Source: iScience

DOI: 10.1016/j.isci.2025.113517

Authors: Kun Zhou, Xintian Zhang, Yu Liang, Han Yao, Yichao Hou, Xingming Zhang, Leilei Du, Wenfeng Wang, Jianhua Wang, Xiangjun Meng

Institutions: Shanghai Jiao Tong University, Shanghai Ninth People's Hospital, Fudan University, Fudan University Shanghai Cancer Center

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Shanghai Lingjun Program, National Natural Science Foundation of China, Shanghai Jiao Tong University

Awards: G1411145141, G3601719579, G5159453156, G5600755993, G6111572103, G6473389142

OpenAlex ID: W4414008338

FWCI: 1.83

Cites: 31

Cited by: 6

Related to: 10