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Neuron-specific enolase as a biomarker in acute ischaemic stroke – a single-centre case-control study

Year: 2025

Type: article

Abstract: Introduction: Early diagnosis of ischaemic stroke and prompt implementation of causal treatment can improve patient outcomes. Recently, special attention has been paid to biomarkers associated with neuronal damage. One of them is neuron-specific enolase (NSE). Studies conducted to date indicate an increase in NSE concentration in patients with acute ischaemic stroke. The aim of this study was to assess serum NSE concentrations in patients with acute ischaemic stroke, and to determine the possible relationship between NSE levels and clinical features of the disease. Materials and methods: This case-control study included 60 patients with acute ischaemic stroke and 60 healthy controls (Opole, Poland, 2023). Demographic and clinical data were collected in the study group, and laboratory tests were performed. NSE concentrations in blood serum were determined in both groups. Results: No statistically significant differences were observed in the mean NSE concentrations between the study and control groups. However, above-normal NSE values were observed significantly more frequently in patients with ischaemic stroke. Significant differences in NSE levels were noted depending on the type of stroke (highest for partial anterior circulation infarct, PACI), stroke aetiology (highest for atherogenic stroke), and the level of disability (highest in completely dependent patients). Above-normal NSE values were also significantly associated with a longer time since the occurrence of ischaemic stroke. Conclusions: The type and aetiology of stroke, time from the first symptoms and degree of dependence influenced the serum concentration of NSE in stroke patients. Further research in this area is warranted.

Source: Aktualności Neurologiczne

DOI: 10.15557/an.2025.0001

Authors: Alicja Sierakowska, Ewa Niewiadomska, Sebastian Łabuda, Anna Bieniasiewicz, Mateusz Roszak, Beata Łabuz-Roszak

Institutions: University of Opole, Medical University of Silesia

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Uniwersytet Opolski