Evaluating left ventricular diastolic function and chamber stiffness in heart failure: the impact of cardiac resynchronisation therapy on diastolic mechanics
Year: 2025
Type: article
Abstract: BACKGROUND: Cardiac resynchronisation therapy (CRT) is a standard treatment for heart failure patients with ventricular conduction delay. While its benefits on left ventricular (LV) systolic function are well-established, the effects on LV diastolic mechanics remain controversial. This study aimed to investigate the interactions between CRT therapy, LV diastolic function, and LV chamber stiffness. METHODS: We evaluated 71 heart failure patients before and six months after CRT using two-dimensional echocardiography. LV volumes, ejection fractions (EF), and diastolic function parameters, including transmitral filling indices, tissue Doppler, and the E/e' ratio, were measured. The LV stiffness index (LV-SI) was calculated using the formula (E / e' lateral) / end-diastolic volume [EDV]). CRT response was defined as a > 15% reduction in LV end-systolic volume. RESULTS: < 0.001). Non-responders showed no significant changes. Baseline parameters for both pulsed-wave and tissue Doppler measurements, as well as LV-SI, showed no significant differences between responders and non-responders. CONCLUSION: This study demonstrates that CRT responders exhibited significant improvements in diastolic function, including measurements of LV filling pressure and active relaxation, as well as a reduction in LV stiffness. Additionally, LV stiffness and diastolic parameters do not appear to influence the response to CRT.
Authors: Sibel Ҫatalkaya, Berat Uğuz
Institution: Bursa City Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414023826