Mitochondrial diagnostics reveal diffuse impairments in skeletal muscle energetics in aging mice
Year: 2025
Type: article
Abstract: This study uses a mitochondrial diagnostic platform to understand how aging and biological sex impact mitochondrial energy transduction. Findings from this diagnostic approach revealed diffuse, but severe, deficits in energy transduction that occur across a broad range of substrate conditions. Given the lack of published data on female aging mice, the work helps fill a gap in the literature regarding sex-dependent and -independent alterations in muscle aging.
Source: Journal of Applied Physiology
Authors: Keon D. Wimberly, Mia Y. Kawaida, Abigail L. Tice, Xiaoping Luo, Jacob A. Lackey, Samuel Alvarez, Lan Wei-LaPierre, Russell T. Hepple, Terence E. Ryan
Institutions: University of Florida, University of Florida Health
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4414029253