Work

Qdenga-induced dengue caused by minor DENV-2 subvariant(s) in the vaccine, with two amino acid substitutions in the E protein

Year: 2025

Type: article

Study design: Case Report

Abstract: Highlight: We describe a Qdenga-induced DENV-2-infection in a Swedish traveller. Comparative sequencing suggests that the vaccine contained a small fraction of identical virus as detected in the patient, suggesting a selection of a DENV-2-substrain with unusual amino acid substitutions. Further research on selection of, and possible effects of, Qdenga-substrain-infections is warranted.

Source: Journal of Travel Medicine

DOI: 10.1093/jtm/taaf091

Authors: John H-O Pettersson, Erica Tibbelin, Gabriel Heyman, Johan Aarum, Oskar Karlsson Lindsjö, Kim Blom, Klara Sondén, Jonas Klingström

Institutions: Uppsala University, Public Health Agency of Sweden, Swedish Veterinary Agency, The University of Melbourne, Peter Doherty Institute, Västmanlands sjukhus Västerås, Umeå University, Karolinska Institutet, Linköping University

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,605

Funder: Åke Wiberg Stiftelse

Award: G2847807455

OpenAlex ID: W4414039327

FWCI: 1.699

Cites: 5

Cited by: 2

Related to: 10