Impact Analysis of Phytometabolites on Oncogene Regulation and Tumor Suppression in Cancer Prevention
Year: 2025
Type: article
Abstract: Phytometabolites, which are beneficial substances that come from plants, have gotten a lot of attention lately because they might help avoid and treat cancer. Flavonoids, terpenoids, alkaloids, and polyphenols are some of these substances. They have many biological actions that change how oncogenes work and how tumors are stopped. This study looks at the molecular and cellular ways that phytometabolites affect important oncogenes and tumor suppressors, which could stop tumors from starting, spreading, and metastasizing. When phytometabolites affect oncogene regulation, they either turn off or on certain signaling pathways that manage cell growth, death, and sprouting. A lot of substances can change the production of oncogenes like c-Myc, K-Ras, and EGFR. These genes are very important in the development of many types of cancer. It is possible for these chemicals to stop the abnormal activity of oncogenes, which stops cells from multiplying and surviving. This could be a good way to avoid cancer. On the other hand, phytometabolites also raise the levels of tumor suppressors like p53, PTEN, and BRCA1/2. These proteins are very important for keeping cells healthy and stopping tumors from growing. Phytochemicals turn on these tumor suppressors, which helps cancer cells fix their DNA, stop the cell cycle, and die. Phytometabolites can also change epigenetic changes that are linked to cancer formation, such as DNA methylation, histone modification, and microRNA control. This may help their chemopreventive benefits even more. Also, the fact that natural goods contain a variety of phytometabolites may make them more effective by working together to target more than one biological process involved in cancer.
Source: Salud Ciencia y Tecnología
Authors: Manish Trivedi, Jyoti Prakash Samal, Kasturi Pohini, Pradeep S, Shikhar Gupta, Sahil Suri, Anand Gudur
Language: English
Topic: Bioactive natural compounds
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4414047811