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A rare case of hepatoid adenocarcinoma of the lung initially presenting as a painful skin nodule

Year: 2025

Type: article

Abstract: Hepatoid adenocarcinoma of the lung (HAL) is a rare and aggressive subtype of pulmonary adenocarcinoma, with cutaneous metastasis being an uncommon clinical manifestation. A 49-year-old male presented with a painful, nodular skin lesion on the upper back. Histopathological examination confirmed it as a cutaneous metastasis of HAL. Subsequent imaging revealed a large primary tumor in the left lung and widespread metastatic disease. Remarkably, the skin lesion was the initial and only presenting feature. This case illustrates the variable clinical presentation of HAL and underscores the need for thorough evaluation of atypical skin lesions.

Source: Journal of Surgical Case Reports

DOI: 10.1093/jscr/rjaf708

Authors: Reem Khabbaza, Ayat Shawish, Alaa Mahmoud, Mohammad Adib Houreih, Moatasem Hussein Al-janabi, Fouz Hassan

Institutions: Latakia University, Korean Dermatological Association, Sociedade Brasileira de Dermatologia

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000