Study of the Association of Tumour Necrosis Factor-α with Chronic Obstructive Pulmonary Disease (COPD)
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory illness characterized by systemic inflammation and limited airflow.Tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine, is believed to play a significant role in its pathogenesis.This study aimed to evaluate the association between serum TNF-α levels and COPD severity, classified according to the GOLD staging system.Methods: The prospective observational study was conducted for a year at the Raipur Institute of Medical Sciences in Raipur.300 clinically stable COPD aged ≥40 years were included using spirometric criteria (post-bronchodilator FEV₁/FVC <0.70).People with asthma, cancer, autoimmune diseases, or recent infections were excluded.ELISA, an enzyme-linked immunosorbent test, was employed to measure blood TNF-α levels.The patients were categorized using GOLD stages I through IV.TNF-α levels were compared between phases, and their relationships with spirometric parameters were investigated using appropriate statistical methods.Results: A total of 95.33% of the participants were men, and their average age was 52.68±7.52 years.There was a statistically significant tendency (p=0.035) of rising TNF-α levels in Stage I (27.53±8.06pg/ml), Stage II (29.86±8.25 pg/ml), Stage III (31.11±8.26pg/ml), and Stage IV (33.10±8.78pg/ml) as the disease severity rose.Conclusion: Elevated systemic inflammation is indicated by serum TNF-α levels, which positively correlate with the severity of COPD.TNF-α may be a useful biomarker for monitoring the disease and assessing risk in COPD.
Authors: Mrutyunjaya Panda, Prangyada Reecha Joshi, Pradosh Samal, Bulu Mahanty
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414065153