Work

TREM-1 as a novel immunotherapeutic target to treat pancreatic ductal adenocarcinoma

Year: 2025

Type: article

Abstract: myeloid cells infiltrate human PDAC tissue. These results suggest that TREM-1 activation could reprogram the immunosuppressive TME, offering a promising strategy for PDAC treatment.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2025.201034

Authors: Lina Gross, Ivanina Mutisheva, Hanne Hillen, Steve Robatel, Martin Wartenberg, Feiyang Ma, Lukas Bäriswyl, Delphine J. Lee, Robert L. Modlin, Kaspar Z’graggen, Mirjam Schenk

Institutions: University of Bern, CK-CARE, Northwestern University, University of California, Los Angeles, The Lundquist Institute, Harbor–UCLA Medical Center

Language: English

Topic: Inflammation biomarkers and pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Awards: Deciphering the role of DC subsets in regulating the immune response to cancer therapies, G880118091

OpenAlex ID: W4414078208

FWCI: 1.192

Cites: 68

Cited by: 4

Related to: 10