Suburethral clear cell carcinoma of Müllerian origin: A case of preservation and discovery
Year: 2025
Type: article
Study design: Case Report
Abstract: Clear cell adenocarcinoma of the urethra is an exceedingly rare malignancy, with fewer than 0.003% of genitourinary cancers in females. We report a unique case of a 63-year-old woman diagnosed with a suburethral clear cell carcinoma of presumed Müllerian origin. The patient presented with intermittent urethral bleeding and a palpable mass. Imaging and cystoscopy confirmed a periurethral cystic lesion without urethral invasion. A transvaginal excision was performed, sparing the urethra and bladder. Histopathology revealed a papillary cystic tumor with clear cytoplasm, mitotic activity, and Müllerian immunohistochemical profile (CK7, Pax-8, HNF-1β positive). This case illustrates the feasibility of organ-preserving surgery in a tumor with typically aggressive behavior. The patient maintained full urinary function postoperatively, emphasizing the importance of individualized surgical planning in such rare malignancies. Long-term follow-up remains essential.
Source: Urological Science
Authors: Ting-Yi Chiang, Chye-Yang Lim, Sheng-Tsung Chang
Institution: Chi Mei Medical Center
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414078783