Year: 2025
Type: article
Abstract: ABSTRACT Memory T cells, a sizable compartment of the mature immune system, enable enhanced responses upon re‐infection with the same pathogen. We have recently shown that virus‐experienced innate acting T (T IA ) cells can modulate infectious or autoimmune diseases through TCR‐independent IFN‐γ production. However, how these cells arise remains unclear. Here, we show that CD4 T IA cells are present in various disease settings hinting towards a disease‐agnostic nature. TCR stimulation and CD28 co‐stimulation are sufficient to induce naïve murine and human CD4 T cells to become capable of cytokine‐mediated, TCR‐independent IFN‐γ responses. In true T IA fashion, adoptive transfer of in vitro‐induced T IA cells in mice yielded a TCR‐independent IFN‐γ response during the innate phase of a Legionella pneumophila infection. Our data thus shows that CD4 T IA cells are more ubiquitous than anticipated and could therefore be involved in more settings than expected.
Source: European Journal of Immunology
DOI: 10.1002/eji.70054
Authors: Nima Yassini, Eva Goljat, Camilla Panetti, Matthias Rath, Nicole Joller
Institution: University of Zurich
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,550
OpenAlex ID: W4414081795