Work

Discovery of Potent and Selective Pyrrolo[2,3- d ]pyrimidine Derivatives as Fourth-Generation EGFR Inhibitors Targeting Triple Mutations

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c01320

Authors: Zhenhua Wu, Xueyan Liu, Xiao-E Yan, Xinyu Wu, Wei Huang, Jiajia Li, Yuanming Xiu, Cairui Lv, Chi Sun, Zheng Wang, Gaoke Xu, Xiaobing Wu, Zhiyu Hu, Huiying Huang, Xin Huang, Jianming Zhang, Cai-Hong Yun, Li Li, Xianming Deng

Institutions: Xiamen University, Shanghai Jiao Tong University, Peking University, Zhongshan Hospital of Xiamen University

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Xiamen Southern Oceanographic Center, Higher Education Discipline Innovation Project, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities

Awards: G1078769645, G1094466701, G1241312116, G2514475877, G2877092936, G3550630099, G4322195117, G4582454429, G710442334, G802675961

OpenAlex ID: W4414082078

FWCI: 4.803

Cites: 53

Cited by: 8

Related to: 10