Work

Brazilin attenuates kidney ischemia-reperfusion injury by regulating inflammation, oxidative stress, and mitochondrial dysfunction.

Year: 2026

Type: article

Abstract: , pretreatment with brazilin significantly downregulated pro-apoptotic Bax and upregulated anti-apoptotic Bcl-2 expression in human renal proximal tubular cells (HK-2) subjected to oxygen-glucose deprivation/reoxygenation (OGD/R). Besides, it ameliorated mitochondrial dysfunction by enhancing mitochondrial biogenesis and restoring mitochondrial membrane potential. These effects collectively suppressed oxidative stress injury and NLRP3 inflammasome signaling pathway activation. In summary, brazilin exhibits significant protective effects against I/R-induced AKI by attenuating inflammation, oxidative stress and cell apoptosis, and mitochondrial damage. These findings suggest that brazilin holds promise as a potential therapeutic agent for AKI.

Source: PubMed

DOI: 10.14670/hh-18-982

Authors: Jinyi Zhao, Lulu Zhang, Fei Mu, Ying Yu, Chen Cui, Meng Tang, Kexin Sun, Yanping Yin, Jingwen Wang, Rui Gong

Institutions: Xijing Hospital, Air Force Medical University, Shaanxi University of Chinese Medicine, Anhui Medical University, Northwest University

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4414082417

FWCI:

Cites:

Cited by:

Related to: 10