Work

Anatomical circuits for flexible spatial mapping by single neurons in posterior parietal cortex

Year: 2025

Type: article

Abstract: Primate lateral intraparietal area (LIP) has been directly linked to perceptual categorization and decision-making. However, the intrinsic LIP circuitry that gives rise to the flexible generation of motor responses to sensory instruction remains unclear. Using retrograde tracers, we delineate two distinct operational compartments based on different intrinsic connectivity patterns of dorsal and ventral LIP. These connections form an anatomical loop with a sensory-like, point-to-point projection from ventral to dorsal LIP and an asymmetric, widespread projection in reverse. In neurophysiological recordings, LIP neurons exhibit motor response fields spatially distinct from their sensory receptive field. Different associations of motor response and receptive fields in single neurons tile visual space. Ventral LIP neurons tend to have motor response fields distant from their sensory receptive fields. This circuit provides the neural substrate to generate the dynamic processes for flexible allocation of attention and motor responses in response to salient or instructive visual input across the visual field.

Source: Communications Biology

DOI: 10.1038/s42003-025-08596-6

Authors: Bashir Ahmed, Hee-kyoung Ko, Maria Rüsseler, Jackson E. T. Smith, Kristine Krug

Institutions: University of Oxford, University of Reading, Center for Behavioral Brain Sciences, Otto-von-Guericke-Universität Magdeburg, Leibniz Institute for Neurobiology

Language: English

Topic: Visual perception and processing mechanisms

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,190