Work

Tailoring Antioxidant Activities: Metal-Type Dependent, Highly Active SOD or Catalase Mimetics

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The failure of the therapeutic administration of superoxide dismutase (SOD) and catalase (CAT) enzymes to prevent oxidative stress has fostered the development of metal complexes that are capable of mimicking their activity. In the present work, two new pyridine azacyclophane ligands capable of coordinating Cu 2+ and Fe 2+ to give rise to mimetics with high activities toward disproportionation of the superoxide anion or hydrogen peroxide, depending on the metal ion, have been prepared. Although the Cu 2+ complexes have some of the highest SOD activities reported to date, they are completely inactive toward H 2 O 2 disproportionation. In contrast, the Fe 2+ complexes catalyze the disproportionation of H 2 O 2 without showing any catalytic SOD activity. Therefore, the type of antioxidant activity of these macrocycles is dictated by the nature of the metal ion, which represents a new approach to the development of potentially useful mimetics.

Source: Inorganic Chemistry

DOI: 10.1021/acs.inorgchem.5c02973