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99mTc/Tricine/HYNIC ubiquicidin 29–41 uptake in a giant cell tumor of the hallux: insights into the importance of time-activity curve analysis for accurate scan interpretation

Year: 2025

Type: article

Abstract: A 37-year-old man presented with swelling and erythema in the left first toe after a prior trauma, suspicious for osteomyelitis. X-ray and computed tomography (CT) scans revealed a radiolucent lesion with cortical disruption. A 99mTc/tricine/HYNIC ubiquicidin 29-41 (UBI) scintigraphy showed increased uptake but a non-accumulative time-activity curve, indicating a false positive for infection. Surgical excision confirmed a giant cell tumor. This case underscores the importance of integrating time-activity curve analysis with target-to-reference ratios in [99mTc]Tc-UBI scintigraphy for accurate diagnosis.

Source: Nuclear Medicine Review

DOI: 10.5603/nmr.106527

Authors: Saeedeh Ataei Nakhaei, Amin Saber Tanha, Kamran Aryana, Nasrin Raeisi, Somaye Barashki

Institution: Mashhad University of Medical Sciences

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414084516

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