Work

Lung volume modulation of sternohyoid muscle function: an anesthetized rat model

Year: 2025

Type: article

Abstract: This study identifies a previously unrecognized mechanism linking lung volume to upper airway patency. We show that lung volume alters both passive and active force generation in the sternohyoid muscle, thereby modulating its impact on upper airway airflow. These findings are likely to inform on emerging therapies for obstructive sleep apnea, involving targeted stimulation of upper airway dilator muscles.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00280.2025

Authors: Charith Horadagoda, Christopher Lambeth, Kristina Kairaitis, Terence Amis

Institutions: The University of Sydney, Westmead Hospital, Westmead Institute for Medical Research

Language: English

Topic: Obstructive Sleep Apnea Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Sydney, Department of Health and Aged Care, Australian Government, National Health and Medical Research Council