Year: 2025
Type: article
Study design: Observational Study
Abstract: PATIENTS AND METHODS: In this multicenter longitudinal study, data from the Spanish Register in AS (AEU-PIEM/2014/0001) were reviewed. The study focused on a cohort of AS patients registered between 2014 and 2019, featuring open inclusion criteria and diverse follow-up strategies. RESULTS: A total of 3315 AS patients were recruited, with 2881 and 434 categorized into the low and intermediate risk groups based on NCCN grouping at inclusion. The median age was 67 years, and only 11% underwent diagnostic biopsy guided by MRI. The median time between follow-up visits was 6.03 months. Over a median follow-up of 62 months (Q1-3: 43.78-85.58), 37% remained in AS, while 8% transitioned to watchful waiting due to aging or intercurrent disease. Death occurred in 199 (6%) of patients, with 3 due to prostate cancer progression and 196 attributed to other causes. At 2 and 5 years, pathological progression-free survival, metastasis-free survival, and active treatment-free survival were 68% and 51%, 99% and 99%, and 70% and 50%, respectively. CONCLUSIONS: Midterm oncological outcomes of AS in Spain align with major international series. We denote underuse of guideline recommendations such as use of MRI or TP Bx for initial PCa characterization. Collaborative efforts are crucial in the search for algorithms, new imaging, or biomarkers to refine indications and transition to active treatments. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02865330.
Source: Cancer Medicine
DOI: 10.1002/cam4.71173
Authors: J. Rubio‐Briones, A. Borque‐Fernando, L. M. Esteban Escaño, A. Wong, A. Guijarro Cascales, E. Gómez Gómez, J. M. Gil Fabra, F. Sanguedolce, F. Gomez‐Veiga, P. A. López González, A. Plata Bello, N. Rodríguez García, M. Montesino Semper, J. F. Suárez Novo, R. Hajianfar, L. l. Fumadó Ciutat, A. González Alfaro, J. M. Duarte Ojeda, A. Bono Ariño, C. Quicios Dorado, A. Loizaga Iriarte, G. García Fadrique, J. M. Giménez Bachs, S. García Barreras, Y. Pallas Costa, A. Vilaseca Cabo, M. Rodrigo Aliaga, F. Campanario Pérez, P. Servián, J. M. Campá Bortoló, M. Soto Delgado, J. M. Rodríguez de Ledesma, C. Sánchez Rodríguez, V. Chantada Abal, Y. E. Hernández Martínez, B. Herrera Imbroda, P. Dolezal, J. Gual Frau, P. Medrano Llorente, J. Moreno Jiménez, J. S. Serrano Uribe, C. B. Congregado Ruiz, A. Reyes, T. Fernández Aparicio, J. García Rodríguez, M. Cuadras Solé, A. García Seguí, J. J. Pacheco Bru, J. Mayor de Castro, A. Mira Moreno, J. L. Molina Suárez
Institutions: Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, Fundación Instituto Valenciano de Oncología, Hospital Universitario Fundación Alcorcón, Hospital Universitario Reina Sofía, Puigvert Foundation, Complejo Hospitalario de Salamanca, Hospital Universitario Virgen de la Arrixaca, Hospital Universitario de Canarias, Hospital Son Llatzer, Hospital Virgen del Camino, Bellvitge University Hospital, Hospital de Sant Joan Despí Moisès Broggi, Hospital Del Mar, Hospital Universitario de Móstoles, Hospital Universitario 12 De Octubre, Hospital General San Jorge, Hospital Universitario Fundación Jiménez Díaz, Hospital de Manises, Hospital General Universitario de Albacete, Hospital Universitario Ramón y Cajal, Hospital General Universitario De Valencia, Hospital Clínic de Barcelona, Hospital General Universitari de Castelló, Complejo Asistencial Universitario de Palencia, Hospital Universitari Germans Trias i Pujol, Hospital Universitario Araba, Hospital Universitario Puerta del Mar, Hospital Terrassa, Hospital Reina Sofía de Murcia, Complexo Hospitalario Universitario A Coruña, Fundación Hospital Manacor, Hospital Clínico Universitario Virgen de la Victoria, Hospital Clínico Universitario Lozano Blesa, Complejo Hospitalario de Jaén, Hospital Universitario Príncipe de Asturias, Hospital Universitario Virgen del Rocío, Hospital General Universitario Morales Meseguer, Hospital Universitario Central de Asturias, Vall d'Hebron Hospital Universitari, Hospital General Universitario de Elche, Hospital Universitari Sant Joan D'Alacant, Hospital General Universitario Gregorio Marañón, Hospital General de Elda, Hospital Virgen del Puerto
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,700
OpenAlex ID: W4414084898