Year: 2025
Type: article
Study design: Case Report
Abstract: Background: is a toxic plant species predominant in South America, known to cause severe liver and kidney damage, and even death, in animal studies. Its toxicity is attributed to carboxyatractyloside, a compound that inhibits the transport of adenosine triphosphate (ATP) into the mitochondria, leading to cellular dysfunction. To date, no cases of human poisoning have been reported. Case report: . A cranial CT scan revealed small intraparenchymal petechial hemorrhages in the biparietal and frontal regions. The patient was started on anticonvulsant and neuroprotective treatment with levetiracetam. Laboratory findings showed markedly elevated transaminases and coagulopathy, which did not improve with vitamin K administration, leading to a diagnosis of acute liver failure. The patient was treated with rifaximin, N-acetylcysteine, and lactulose, showing progressive improvement in liver function. After 27 days in the pediatric intensive care unit (ICU), he was transferred to the general ward hemodynamically stable but with persistent neurological impairment, unable to speak or respond to stimuli. Conclusion: highlights the plant's potential neurotoxic and hepatotoxic effects in humans. The absence of prior human cases poses challenges in management and prognosis, emphasizing the need for increased awareness among healthcare professionals and further research on its toxicological impact.
Source: Frontiers in Medicine
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4414086658