Work

Successful rescue of PD-1 inhibitor-induced TEN by vincristine combination therapy: a case report and literature review

Year: 2025

Type: article

Abstract: With the growing use of immune checkpoint inhibitors (ICIs) in the management of various solid malignancies, immune-related adverse events (irAEs) are increasingly recognized. Toxic epidermal necrolysis (TEN), though rare, represents a severe and potentially fatal cutaneous irAE with a high mortality rate. Owing to its low incidence and limited clinical data, a standardized treatment approach for ICI-induced TEN has not been established. We present a patient who developed TEN following the administration of a programmed cell death-1 inhibitor. The patient was successfully managed with a combination of vincristine, intravenous immunoglobulin, and glucocorticoids at the Department of Oncology, Guangzhou Chest Hospital.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1621494

Authors: Hui-Yi Huang, Jia-Qi Liu, Yun-Yun Zeng, Zhi-Hao Huang, Shan Su

Institution: Guangzhou Chest Hospital

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801