Work

Green Synthesis of Stereodefined Tri- and Tetrasubstituted Alkenes via 100% Atomeconomic and Regio-, and Stereoselective Halo-chalcogenation and Sulfonylation of Alkynes

Year: 2025

Type: article

Abstract: Achieving 100% atom economy in an organic transformation is a challenging task but it is always desirable in the context of green chemistry. Difunctionalization of alkynes using a bifunctional reagent is a useful strategy to achieve 100% atom economy, however, the challenge is to control the regio- and stereoselectivity of the reaction. In this article, we discuss the recent advances in developing 100% atom economic, highly regio- and stereoselective halo-chalcogenation and chlorosulfonylation strategies with alkynes for the green and sustainable synthesis of stereodefined tri- or tetrasubstituted alkenes, and its application in accessing valuable molecules including a marketed drug in a green and sustainable manner. The green chemistry metrics are presented to highlight the greenness of some of these protocols.

Source: CHIMIA International Journal for Chemistry

DOI: 10.2533/chimia.2025.622

Authors: Appanapalli N.V. Satyanarayana, Tanmay Chatterjee

Institutions: Birla Institute of Technology and Science - Hyderabad Campus, Birla Institute of Technology and Science, Pilani

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: CSIR-Structural Engineering Research Centre, Science and Engineering Research Board

Awards: G1120287885, G5180958106