Work

Gender-Specific Associations of CYP4F2 (rs1558139) Gene Polymorphism and Serum Levels in Early and Exudative Age-Related Macular Degeneration

Year: 2025

Type: article

Abstract: BACKGROUND: rs1558139 gene polymorphism, serum CYP4F2 levels, and the development of age-related macular degeneration (AMD). MATERIALS AND METHODS: A total of 204 patients with early AMD, 204 patients with wet AMD, and 294 healthy individuals as controls participated in this study. Genotyping of rs1558139 was carried out using real-time polymerase chain reaction (RT-PCR), while levels of serum CYP4F2 protein were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: rs1558139 was statistically significantly less frequent in females with early AMD than in the control females (46.8% vs. 54.77%, p=0.037). However, in the exudative AMD group, the AA genotype was more frequent in women than in men (31.9% vs. 17.3%, p<0.001). Serum CYP4F2 concentration was higher in early and exudative AMD groups than in controls (5.394 (3.554) vs. 1.599 (4.142), p=0.013 and 8.422 (8.356) vs. 1.599 (4.142), p<0.001, respectively). CONCLUSIONS: rs1558139 polymorphism shows gender-specific associations with AMD. The A allele is less frequent only in females with early AMD, while the AA genotype is more common in women with exudative AMD. A higher serum CYP4F2 level may contribute to the development of AMD.

Source: Cureus

DOI: 10.7759/cureus.91988