Work

Two-pronged immune evasion of pseudouridine-modified RNA

Year: 2025

Type: article

Abstract: Ψ) suppress unwanted immunogenicity of RNA-based therapeutics. However, molecular mechanisms governing such immune evasion remain elusive. In a recent article, Bérouti, Wagner, and colleagues show that Ψ impairs the processing of Toll-like receptor (TLR)-agonistic ligands and hinders TLR activation.

Source: Trends in Molecular Medicine

DOI: 10.1016/j.molmed.2025.08.007

Authors: Jonas Cerneckis, Yanhong Shi

Institutions: City Of Hope National Medical Center, City of Hope, Beckman Research Institute

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030