Year: 2025
Type: article
Study design: Case Report
Abstract: In multiple myeloma (MM), intracranial involvement is rare, particularly in cases of dural involvement. Cranial plasmacytoma can be seen in MM and may occasionally present as a solitary lesion. On MRI, dural plasmacytomas can mimic other extra-axial masses such as meningiomas, metastases, lymphomas, or sarcomas of the dura mater. A 66-year-old woman presented with a right occipital swelling identified on an external MRI scan, which was accompanied by a headache. The MRI suggested MM or parieto-occipital intraosseous meningioma. The patient was advised to undergo a follow-up MRI, which she did not attend. Three months later, a head CT scan revealed that the mass had regressed spontaneously, and she remained asymptomatic. For that reason, she declined treatment. Five months later, the patient returned with left-sided hemiparesis. Follow-up imaging showed significant growth of the tumor. After tumor extraction, histopathological analysis with immunohistochemistry revealed a plasma cell neoplasm with lambda light chain. Prior to making treatment decisions, it is crucial to conduct a thorough systemic evaluation and preoperative workup for MM when plasmacytoma is considered in the differential diagnosis.
Source: Cureus
DOI: 10.7759/cureus.91986
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414091218