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Brucellosis. A Rare Cause of Biliary Dysplasia and Ampullary Adenocarcinoma?

Year: 2025

Type: article

Abstract: Brucellosis, a zoonotic bacterial infection often characterized by nonspecific symptoms including fever, night sweats, and weight loss, has a prolonged and recurrent course, often leading to chronic symptoms if inadequately treated. Hepatic involvement is well-documented with manifestations ranging from mild hepatitis to hepatic abscesses and granulomas. However, the association of brucellosis with biliary dysplasia or ampullary adenocarcinoma has not been previously reported in medical literature. We present a 68-year-old man with hepatic granulomatosis due to chronic brucellosis complicated by numerous episodes of ascending cholangitis secondary to choledocholithiasis and common bile duct strictures, with high-grade dysplasia and development of ampullary adenocarcinoma.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001827

Authors: Zachary Vinton, Kevin Wolfe, Sean MacBride, Thomas Heffron, Vimal Jhaveri, Andrea K. Sotelo, Mark Rosenblatt, Clark Kulig, Matthew Stotts

Institutions: University of Nebraska Medical Center, Porter Adventist Hospital, Infectious Disease Consultants, Presbyterian St. Luke's Medical Center, University of Colorado Health

Language: English

Topic: Brucella: diagnosis, epidemiology, treatment

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414094555

FWCI:

Cites: 10

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Related to: 10